According to Weiss, the upcoming batch of "Entourage" eps will pick up where the show's fourth season left off: the disastrous Cannes screening of "Medellin." The show's characters must suck up the financial hit they took from funding the dog of a project -- and what it means to Vince's acting (and Eric's managing) career.

"It could be a pretty interesting season," Weiss said. "It will be very true to what you see actors go through after a movie like that."